Dapagliflozin is a prescription oral medication widely used to treat adults with type 2 diabetes, heart failure, and chronic kidney disease (CKD). Belonging to the class of SGLT2 inhibitors (sodium-glucose cotransporter-2 inhibitors), it works by helping the kidneys eliminate excess glucose through urine, thereby lowering blood sugar levels.
Approved Medical Uses of Dapagliflozin
1. Type 2 Diabetes Mellitus
Dapagliflozin helps regulate blood sugar levels by promoting the elimination of excess glucose through the urine. It operates independently of insulin, making it effective for those with insulin resistance.
2. Heart Failure with Reduced Ejection Fraction (HFrEF)
It lowers the risk of hospitalization and cardiovascular death in patients diagnosed with HFrEF.
3. Chronic Kidney Disease (CKD)
Dapagliflozin supports long-term renal function and reduces the risk of progression to kidney failure, even in non-diabetic individuals.
Key Benefits of Dapagliflozin
- Lowers blood sugar without stimulating insulin production
- May assist in modest weight reduction
- Slight reduction in blood pressure
- Cardio-renal protective properties
Common Side Effects
- Genital yeast infections (more common in women)
- Frequent urination due to glucose excretion
- Higher risk of urinary tract infections (UTIs)
- Dizziness due to dehydration or hypotension
- Uncommon instances of diabetic ketoacidosis (DKA), often presenting with symptoms like nausea, tiredness, and vomiting
Serious Warnings & Risks
- Euglycemic Diabetic Ketoacidosis: Can develop despite having normal blood sugar levels
- Risk of Lower Limb Amputation: Rare, but should be monitored
- Fournier’s Gangrene: A rare yet life-threatening infection affecting the tissues around the genitals and perineal area
- Acute Kidney Injury: Especially in dehydrated individuals
- Mild LDL Cholesterol Increase
Recommended Dosage
Standard Dose: 10 mg taken orally once daily, with or without meals
Renal Function Limitations:
- Not recommended for patients with eGFR < 25 mL/min/1.73 m² (for diabetes)
- Not advised for CKD patients with eGFR < 20 mL/min/1.73 m²
Who Should Avoid Dapagliflozin?
- Individuals with type 1 diabetes may significantly increase risk of diabetic ketoacidosis (DKA)
- Patients with significant kidney impairment
- Anyone allergic to dapagliflozin or related compounds
Potential Drug Interactions
- Diuretics: May increase dehydration and blood pressure reduction
- Insulin or Sulfonylureas: Raise the risk of hypoglycemia
- Other SGLT2 Inhibitors: Avoid combining due to overlapping side effects
Where to Buy Dapagliflozin Online?
Planning to buy dapagliflozin 10 mg safely online? If you’re located in cities like Santo Domingo, Santiago, Punta Cana, La Romana, or San Cristóbal, ensure you purchase only from certified pharmacies or authorized pharmaceutical exporters. Always verify product authenticity, global shipping terms, and pricing before completing your order. For safe and reliable sourcing, consider Amber Lifesciences Pvt. Ltd., a trusted Indian exporter of pharmaceutical products.
Why Choose Amber Lifesciences Pvt. Ltd.?
Based in Navi Mumbai, India, Amber Lifesciences Pvt. Ltd. is a leading pharmaceutical manufacturer and exporter to Latin American countries such as Guadeloupe, Martinique, Puerto Rico, Cuba, Haiti, and the Dominican Republic. The company offers:
- Regulatory support with full dossier preparation
- Customized international packaging
- Distribution in over 40 countries worldwide
Conclusion
Dapagliflozin is a clinically established solution for managing type 2 diabetes, CKD, and heart failure—either alone or alongside treatments like metformin. Always consult your healthcare provider before starting or altering any medication plan.