Buy Human Fibrin Sealant Online is a topical hemostatic agent designed to control bleeding during surgery when conventional techniques, such as sutures or cautery, are insufficient. It simulates the concluding steps of the body’s natural clotting mechanism through components sourced from human plasma. It offers a fast, effective, and biodegradable solution for mild to moderate bleeding in surgical settings.
Key Product Information – Buy Now
- Generic Name: Fibrin Sealant (Human)
- Brand Name: Raplixa™ (formerly Fibrocaps™)
- Manufacturer: Originally developed by ProFibrix BV, acquired by The Medicines Company, now part of CSL Behring
- FDA Approval: 2015
- Formulation: Lyophilized powder (reconstituted before use)
Composition of Human Fibrin Sealant
It consists of:
- Human Fibrinogen: Derived from pooled human plasma.
- Human Thrombin: Initiates fibrin formation from fibrinogen.
- Calcium Chloride: A cofactor essential for clot stabilization.
These components work together to replicate the final steps of the coagulation cascade, forming a strong and stable fibrin clot.
Indications and Use – Exporter India
Human Fibrin Sealant is used to support hemostasis during surgical procedures involving:
- Vascular procedures
- Orthopedic operations
- General surgeries (e.g., liver resections, soft tissue bleeding)
It is especially beneficial for patients where bleeding is mild to moderate and not effectively controlled by standard methods.
Administration
- Route: Topical application during surgery
- Form: Lyophilized powder to be reconstituted
- Method: Spray applicator or direct application to the bleeding site
Mechanism of Action – Available for Surgical Use in Latin American Countries such as Nicaragua, Mexico, and Honduras
- Thrombin activates fibrinogen, converting it to fibrin.
- The fibrin clot forms at the bleeding site.
- The clot is biodegradable and is naturally absorbed by the body.
This localized clotting ensures effective bleeding control without systemic coagulation risk.
Safety and Side Effects of Human Fibrin Sealant
Common Side Effects:
Local inflammation, mild allergic reactions (itching, redness)
Rare but Serious Side Effects:
- Thromboembolic events (if systemically absorbed)
- Hypersensitivity reactions due to human plasma proteins
- Theoretical risk of transmitting infectious agents (due to human origin)
Contraindications
- Known allergies to human fibrinogen, thrombin, or other human plasma products
- Not suitable for controlling major arterial or venous bleeding
- Exercise caution when administering to patients with a prior history of thrombosis
Comparison to Other Fibrin Sealants
| Feature | Raplixa™ | Tisseel™ (Baxter) | Evicel™ (Ethicon) |
|---|---|---|---|
| Form | Powder | Liquid/Premixed | Liquid/Premixed |
| Application | Spray/Direct | Dual-syringe Spray | Dual-syringe Spray |
| Storage | Refrigerated | Frozen (thawed before use) | Refrigerated |
Advantage: Human Fibrin Sealant does not require thawing, offering easier storage and quicker surgical readiness.
Clinical Evidence
Human Fibrin Sealant was evaluated in the STOP-Bleeding clinical trials, which demonstrated its effectiveness in reducing the time to hemostasis. It has also shown potential use in medicine and trauma surgery for fast and reliable bleeding control.
Availability & Pricing
- Availability: Primarily used in hospital surgical settings
- Cost: Generally high, consistent with biologic hemostatic agents
Amber Lifesciences Pvt Ltd – Trusted Pharma Exporter
Amber Lifesciences Pvt Ltd is a leading third-party pharmaceutical manufacturing company and the biggest pharma exporter in India. With a commitment to quality, compliance, and global standards, the company specializes in supplying a wide range of surgical and hospital-use products, including fibrin sealants like this medicine. Recognized among the top pharmaceutical exporters in India, Amber Life Sciences partners with healthcare providers and distributors worldwide to deliver safe and effective solutions tailored to medical needs.
Conclusion – Place Your Order Now
Human Fibrin Sealant is a reliable, easy-to-use topical hemostatic agent designed to support surgeons in managing bleeding during complex procedures. Its convenient powder form, minimal preparation time, and strong clotting action make it a top choice among leading pharmaceutical manufacturers and exporters to LATAM countries like Chile, Nicaragua, Mexico, Honduras, Guatemala.
